구강편평상피세포암 조직에서의 Microsatellite 불안전성 및 p53 유전자 돌연변이 분석
Microsatellite Iinstability and p53 Gene Mutation in Oral Squamous Cell Carcinoma
소속 상세정보
최태호/Tae Ho Choi
장현중/김진수/정운복/홍수형/김진아/나선영/김정완/손윤경/Hyun Jung Jang/Chin Soo Kim/Woon Bok Chung/Su Hyung Hong/Jin A Kim/Sun Oung Na/Jung Wan Kim/Yoon Kyung Sohn
KMID : 0355620000260040337
Abstract
- 요약 -
본 연구에서는 MSI와 구강암과의 상관관계를 규명하기 위하여 17례의 구강암에 대하여
12 종류의 marker를 이용하여 MSI 빈도를 조사하였으며, 동시에 p53 단백의 과발현과 유전
자 돌연변이 양상에 대해서도 알아보았다. 그 결과 4종류 이상의 marker에 대해서 MSI가
나타나는 widespread MSI의 경우 임상병리학적으로 뚜렷한 특징이 없었다. 또한 흡연과
MSI 빈도간에도 연관성이 없었으나 흡연은 p53 유전자의 돌연변이를 증가시켜 암화과정을
촉진하는 작용을 하는 것으로 나타났다.
#초록#
-Abstract-
Germ-line mutations at DNA repair loci confer susceptibility to colon cancer in
hereditary non-polypopsis colorectal cancer. Somatic loss of DNA mismatch repair gene
has been reported in a large variety of other tumor types. Replication errors(RERs)
judged by microsatellite instability(MSI) and its associated mutations have been
recognized as an important mechanism in various tumor types.
To investigate associations between MSI and oral squamous cell carcinoma, the
frequency of MSI using 12 microsatellite markers were analyzed for the series of the
series of oral tumors. Of 17 tumors, 8 cases(47%) did not show instability at any of the
12 loci ; 5(29%) showed instability at 2∼3 loci ; and 4(24%) showed instability above 4
loci.
The 4 cases showing widespread MSI did not differ from those without evidence of
instability in terms of age at diagnosis, degree of differentiation, metastasis to lymph
node, tumor location or the presence of mutations in the p53 tumor suppressor gene.
DCC and D17S 796 were the most frequently detected in MSI analysis.
There were no correlation between smoking and MSI frequency, instead, smoking was
suggested to increase the mutation rate of p53 and development of oral carcinomas.
키워드
Microsatellite instability(MSI); Oral squamous cell carcinoma; p53;
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